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Older Macs can play HEVC files just fine, but only the newest models have chips fast enough to encode HEVC decently. If you don't have a Mac made from 2017 onward, stick with H.264. H.265 or HEVC makes files even smaller - but requires hefty processing power to crunch the necessary numbers. Tried-and-true H.264 converts relatively quickly, and it can squeeze a high-def Blu-ray file onto a DVD's worth of space or less.
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The first two aren't worth considering with the latter two available.
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HandBrake offers a choice of four compression algorithms: MPEG-2 (oldest, relatively lousy), MPEG-4 (still old, not great), H.264 (old, faster, pretty good), and HEVC/H.265 (new, slower, even better). HEVC: Which compression algorithm is best? Let's discuss a couple of the choices you'll need to weigh before you start putting your videos through the wringer.
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